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KMID : 0545119990090050572
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Journal of Microbiology and Biotechnology
1999 Volume.9 No. 5 p.572 ~ p.575
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Antibacterial Activity of Antimycotic Miconazole against Methicillin-Resistant Staphylococcus aureus
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Lee Sang-Hwa
Kim Chang-Jin
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Abstract
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Miconazole was estimated to have a minimum inhibitory concentration of 0.78 ㎍/㎖ against the methicillin-resistant strains of Staphylococcus aureus (MRSA). The antibacterial activity of miconazole against MRSA was bacteriostatic in cation-adjusted Mueller-Hinton broth, but bacteriocidal in saline solution. The anti-MRSA activity of miconazole did not show a significant change under the susceptibility-testing conditions such as various inoculum sizes, pHs, or cations (Ca^++ or Mg^++) which was added to the medium. However, the anti-MRSA activity of miconazole was completely suppressed by lipophilic a-tocopherol (50 ㎍/㎖), but definitely not by water-soluble ascorbic acid.
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